Christos D. Katsetos, M.D., Ph.D., FRCPath

Education

M.D. (1983) St. George's University School of Medicine, Grenada, West Indies

Dr.philos. (Ph.D.) Neuropathology (2002) The Gade Institute, University of Bergen, Norway http://www.uib.no/info/dr_grad/2002/katstetos.htm

Specialty Area

General and Pediatric Neuropathology (Clinical/Diagnostic)

Experimental Neuropathology, Histochemistry and Cell Biology of the Cytoskeleton (Research)

Postgraduate Training

Resident in Anatomic Pathology (1983-85), Shadyside Hospital, Pittsburgh, Pennsylvania

Fellow in Neuropathology (1985-87), Brown University at Rhode Island Hospital and The Miriam Hospital, Providence, Rhode Island

Fellow in Neuropathology (1987-89), University of Virginia Hospitals, Charlottesville, Virginia

Fellow in Anatomic Pathology (1989-90), Beth Israel Medical Center, New York, NY

Academic Appointments

Assistant Professor, Departments of Pathology & Laboratory Medicine, Neurology and Neurosurgery (1990-94), Hahnemann University, Philadelphia, Pennsylvania

Assistant Professor, Department of Pathology & Laboratory Medicine (1994-95), Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania

Research Assistant Professor, Department of Microbiology & Immunology (1996-98), Temple University School of Medicine, Philadelphia, Pennsylvania

Research Associate Professor, Department of Pediatrics (1998-2003), MCP Hahnemann University, Philadelphia, Pennsylvania

Co-director, Neurology Research Laboratory (1998-present), St. Christopher's Hospital for Children, Philadelphia, Pennsylvania

Research Professor, Department of Pediatrics (2003-present), Drexel University College of Medicine, Philadelphia, Pennsylvania

Research Professor, Department of Pathology & Laboratory Medicine (2006-present), Drexel University College of Medicine, Philadelphia, Pennsylvania (joint appointment)

Member, Graduate Program in Neuroscience (2006-present), Drexel University College of Medicine

Clinical/Medical Staff Appointments

Director of Neuropathology (1991-94), Hahnemann University, Philadelphia, Pennsylvania

Neuropathologist (1998-present), Section of Neurology and Department of Pathology & Laboratory Medicine, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania

Medical Licensure

License without restriction, Commonwealth of Pennsylvania

License without restriction, New York State

Clinical/Diagnostic Interests

Brain tumors, perinatal hypoxic-ischemic encephalopathy, cerebrovascular disease, demyelinating and immune-mediated diseases of the CNS, autopsy neuropathology, and muscle and nerve pathology.

Selected Honors & Awards

Recipient of Honorary Plaque for Professional Achievements in Pathology Research (1996), Department of Pathology, University of Ioannina, Medical School, Greece

Member of the Royal College of Pathologists (MRCPath) by Published Works (2000)

Promoted to Fellowship of the Royal College of Pathologists (FRCPath) (2006)

Established Investigator Award (2004-2006), St. Christopher's Foundation for Children

Editorial Board Member, Journal of Neuropathology & Experimental Neurology (2007-2010)

Membership in Professional Societies

Member, American Association of Neuropathologists

Member, American Society for Investigative Pathology

Member, Federation of American Societies for Experimental Biology

Member, Royal College of Pathologists, UK

Member, British Neuropathological Society, UK

Member, International Society of Neuropathology

Research

During the past two decades, my research has focused on cellular aspects of growth and differentiation of human embryonal tumors of the nervous system (medulloblastomas, neuroblastomas and retinoblastomas) and on molecular aspects of viral neuro-oncogenesis.

Currently, my research focuses primarily on alterations of the microtubule cytoskeleton and centrosomes in human brain tumors with emphasis on diffuse astrocytic gliomas.

I am also presently involved in collaborative projects focusing on:

• Calcium and nitric oxide-mediated neuronal damage during CNS hypoxia-ischemia in the newborn and neonatal seizures (using experimental animal models)
• Immunopathogenesis and neuropathogenesis of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease as a model of multiple sclerosis
• Clinico-pathological studies covering a wide range of pediatric neuropathology topics, including brain tumors, cerebrovascular disease, epilepsy and immune-mediated CNS diseases.